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In addition to p16 and ARF, this gene generates four other isoforms
as a result of option splicing. This gene encodes two proteins, p16 and p14ARF,
which are transcribed from the similar second and 3rd exons
but substitute 1st exons: p16 from exon 1α and ARF
from exon 1β. As a result, they are translated from distinctive reading frames and thus have totally distinct
amino acid sequences. Aliases CDKN2A, CDK4I,
CDKN2, CMM2, INK4, INK4A, Mlm, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4,
P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF.
16 inhibits cyclin dependent kinases four and 6 (CDK4
and CDK6) and thereby activates the retinoblastoma (Rb) relatives of proteins, which block traversal
from G1 to S-phase. 14ARF (recognized as p19ARF in the mouse) activates the p53 tumor suppressor.
Both act as tumor suppressors by regulating the mobile cycle.
Kim, Dong (November 23, 2010). 北 해안포 도발 감행,
연평도에 포탄 200여발 떨어져. Riyadi,
Slamet (November 11, 2010). "Flights resume to Indonesia as volcano spews ash".
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Cotter, Holland (May 6, 2010). "Another auction, a different trophy".
May 7, 2010). "A draft sequence of the Neanderthal genome". -
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